NAD+ is a critical coenzyme for cellular energy production, DNA repair, and sirtuin activity, with levels known ...

Poly(ADP‐ribose) polymerases (PARPs) are a family of enzymes that play a crucial role in maintaining genomic integrity by detecting DNA damage and facilitating its repair. By catalysing the covalent ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and ...

Researchers decode repair mechanism during transcription of genetic information. Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

Deinococcus radiodurans is renowned for its extraordinary resistance to ionising radiation and other environmental stresses. This bacterium employs a combination of passive and active mechanisms to ...

U.S. Fast Track designation of ART6043 underpinned by promising clinical data to date and high unmet need in gBRCA-mutated HER2-negative breast ...